Current evidence shows that IV Ketamine has a rapid-onset (within 1-2 days) efficacy with depression


In clinical trials ketamine has demonstrated antidepressant effects in up to 70% of patients


Most insurances will provide reimbursement for TMS as an second-line  treatment

O U R  A P P R O A C H

At CAC we offer ketamine infusions and ketamine assisted CBT as an adjunct treatment options for patient with treatment resistant depression or acute suicidal thoughts or actions. Although intravenous ketamine has not been FDA approved, current research indicates that it provides an important secondary approach to a significant number patients who may have exhausted more traditional means.  Although it is likely that there are multiple mechanisms at play scientists believe that ketamine works by modulating the activity of a brain chemical called glutamate.  This chemical then stimulates the growth of new synapses in that brain that help alleviate depressive symptoms.  Although ketamine is not a treatment for everyone, it has been a life changing option for many. By coming to the Cincinnati Anxiety Center, you can be sure that you or your loved one will receive compassionate and effective care from experts committed to helping you achieve the best possible outcome.



No Gimmicks Just Science


In a matter of hours this molecule can make a significant difference in the lives of patients suffering from depression.  Set up a consultation today because the next 24 hours could change the trajectory of your recovery.

Ketamine FAQs

How does ketamine work?

There is a degree of speculation involved but one important target for ketamine is NMDA receptors in the brain. Ketamine binds to these receptors and increases the availability of a neurotransmitter called glutamate in the spaces between neurons. Glutamate also activates the connections in the AMPA receptor. It is the cobination of the blocking of NMDA and activation of AMPA receptors that that leads to a process called synaptogenesis. It is this process likely yields the positive antidepressant effects.

How long do effects last?

There are questions about the durability of effects of ketamine and that is why at CAC it is used as part of integrated treatment program that can include medication, CBT, and TMS. Recent results from meta-analysis seem to indicate that a single-dose ketamine administration will likely hold it's effects for 3–7 days. Alternatively, a repeated-dose of intravenous racemic ketamine appears to last up to 2–3 weeks. As a general outcome in clinical trials most patients relapse within 1 month of administration without repeated ketamine administrations or other supplemental treatments. Ketamine is best seen one tool in a broader array of treatments.

Will insurance cover ketamine infusions?

Although ketamine is FDA approved as an anesthetic, it is considered off-label as a psychiatric treatment. This is due to a number of reasons unrelated to it's efficacy, but suffice to say that reimbursement varies widely among insurance companies. We would recommend we would advise that you check ahead of time with your insurance provider to be aware of their policies. We will provide you with the CPT codes to submit to your insurance company if eligible for out-of-network benefits.

How much will treatment cost?

Our prices reflect our commitment to making this treatment accessible. Our clinic has a flat rate of $300 dollars per ketamine infusion. A typical treatment course may run up to six infusions.

Are there safety concern with ketamine?

Ketamine is considered relatively safe in a medical setting, because it does not affect the protective airway reflexes, and it does not depress the circulatory system, as other anesthetic medications do. However, as with any drug there can be some side effects that should be carefully monitored. These include, but not limited to, psychiatric (e.g., dissociation), neurologic/cognitive, genitourinary, and hemodynamic effects. The most common effect seen in practice is dissasociation, which means it can temporarily make patients feel as though they are becoming somewhat detached from reality.